NME1 can also be called NDPKA (Nucleoside phosphate kinase A), NM23 (Metastasis inhibitor factor nm23), and GAAD(Granzyme A activated DNase). It is part of the NDK family. NME1 was discovered because it has a reduced mRNA transcript level in highly metastatic cells.
Nucleoside diphosphate kinase is a hexamer that is composed of 'A (encoded in this gene) as well as 'B (encoded via NME2) isoforms. In aggressive neuroblastomas, mutations in this gene were identified. This gene has been affected by two transcript variants that encode different isoforms. You can buy high –quality NME1 antigen equipment via the internet.
This gene has been co-transcribed with the neighboring gene NME2. They encode a fusion protein that shares sequence identity with each gene product. NME/NM23 nucleoside diphosphate kinase kinase1 (NME1), an endoplasmic reticulum-associated SET-complex component that contains pp32 (GzmA), and pp32 substrates.
This gene encodes this protein and is found on chromosome 17q22. NME/NM23 nucleoside phosphate kinase 1- (NME1) plays a major role in tumor metastasis suppression. It binds and nicks the nuclease-hypersensitive element (NHE) of the c-myc promoter, recognizes the S1 nuclease-hypersensitive region (5'-SHS silencer) and the NHE basal promoter of platelet-derived growth factor.
It activates to nick DNA and translocates from the endoplasmic reticulum to the nucleus. This initiates single-stranded damage. The NDK/NME/NM23 protein kinase (encoded in the gene) family consists of at least eight distinct proteins with different cellular localization. This group is capable of inhibiting metastasis in many types of tumor cells.